Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells
Identifieur interne : 003212 ( Main/Exploration ); précédent : 003211; suivant : 003213Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells
Auteurs : S. Seah [Singapour] ; I C C. Low [Singapour] ; J L Hirpara [Singapour] ; K. Sachaphibulkij [Singapour] ; G. Kroemer [France] ; C. Brenner [France] ; S. Pervaiz [Singapour, Australie]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2015.
Descripteurs français
- KwdFr :
- Acide peroxynitreux (pharmacologie), Antinéoplasiques (pharmacologie), Apoptose (), Cisplatine (pharmacologie), Espèces réactives de l'azote (métabolisme), Humains, Ligand TRAIL (pharmacologie), Lignée cellulaire tumorale, Microdomaines membranaires (métabolisme), Récepteurs au TRAIL (métabolisme), Résistance aux médicaments antinéoplasiques, Synergie des médicaments, Transduction du signal, Transport de protéines.
- MESH :
- métabolisme : Espèces réactives de l'azote, Microdomaines membranaires, Récepteurs au TRAIL.
- pharmacologie : Acide peroxynitreux, Antinéoplasiques, Cisplatine, Ligand TRAIL.
- Apoptose, Humains, Lignée cellulaire tumorale, Résistance aux médicaments antinéoplasiques, Synergie des médicaments, Transduction du signal, Transport de protéines.
English descriptors
- KwdEn :
- Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Cell Line, Tumor, Cisplatin (pharmacology), Drug Resistance, Neoplasm, Drug Synergism, Humans, Membrane Microdomains (metabolism), Peroxynitrous Acid (pharmacology), Protein Transport, Reactive Nitrogen Species (metabolism), Receptors, TNF-Related Apoptosis-Inducing Ligand (metabolism), Signal Transduction, TNF-Related Apoptosis-Inducing Ligand (pharmacology).
- MESH :
- chemical , metabolism : Reactive Nitrogen Species, Receptors, TNF-Related Apoptosis-Inducing Ligand.
- chemical , pharmacology : Antineoplastic Agents, Cisplatin, Peroxynitrous Acid, TNF-Related Apoptosis-Inducing Ligand.
- drug effects : Apoptosis.
- metabolism : Membrane Microdomains.
- Cell Line, Tumor, Drug Resistance, Neoplasm, Drug Synergism, Humans, Protein Transport, Signal Transduction.
Abstract
Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms underlying resistance to cisplatin and unraveling surrogate signaling networks that could revert sensitivity to apoptosis stimuli. We made use of three different sets of cell lines, A549 and H2030 non-small-cell lung cancer (NSCLC) and A2780 ovarian cancer cells and their cisplatin-resistant variants. Here we report that cisplatin-resistant cell lines displayed a multidrug-resistant phenotype. Changes in mitochondrial metabolism and defective mitochondrial signaling were unraveled in the resistant cells. More interestingly, a marked increase in sensitivity of the resistant cells to death receptor-induced apoptosis, in particular TRAIL (TNF-related apoptosis-inducing ligand)-mediated execution, was observed. Although this was not associated with an increase in gene transcription, a significant increase in the localization of TRAIL death receptor, DR4, to the lipid raft subdomains of plasma membrane was detected in the resistant variants. Furthermore, exposure of cisplatin-resistant cells to TRAIL resulted in upregulation of inducible nitric oxide synthase (iNOS) and increase in nitric oxide (NO) production that triggered the generation of peroxynitrite (ONOO−). Scavenging ONOO− rescued cells from TRAIL-induced apoptosis, thereby suggesting a critical role of ONOO− in TRAIL-induced execution of cisplatin-resistant cells. Notably, preincubation of cells with TRAIL restored sensitivity of resistant cells to cisplatin. These data provide compelling evidence for employing strategies to trigger death receptor signaling as a second-line treatment for cisplatin-resistant cancers.
Url:
DOI: 10.1038/cddis.2015.299
PubMed: 26492363
PubMed Central: 4632318
Affiliations:
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Seah</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Low, I C C" sort="Low, I C C" uniqKey="Low I" first="I C C" last="Low">I C C. Low</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirpara, J L" sort="Hirpara, J L" uniqKey="Hirpara J" first="J L" last="Hirpara">J L Hirpara</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Science Institute, National University Health System</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sachaphibulkij, K" sort="Sachaphibulkij, K" uniqKey="Sachaphibulkij K" first="K" last="Sachaphibulkij">K. Sachaphibulkij</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Equipe 11 Labellisée par la Ligue Contre le Cancer, Centre de Recherche des Cordeliers</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>INSERM, U1138</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Université Pierre et Marie Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, C" sort="Brenner, C" uniqKey="Brenner C" first="C" last="Brenner">C. Brenner</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>INSERM UMR-S 1180, LaBex LERMIT, University of Paris Sud</institution>, Châtenay-Malabry,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pervaiz, S" sort="Pervaiz, S" uniqKey="Pervaiz S" first="S" last="Pervaiz">S. Pervaiz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>National University Cancer Institute, National University Health System</institution>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>School of Biomedical Sciences, Curtin University</institution>, Perth, Western Australia,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Death & Disease</title><idno type="eISSN">2041-4889</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Cell Line, Tumor</term><term>Cisplatin (pharmacology)</term><term>Drug Resistance, Neoplasm</term><term>Drug Synergism</term><term>Humans</term><term>Membrane Microdomains (metabolism)</term><term>Peroxynitrous Acid (pharmacology)</term><term>Protein Transport</term><term>Reactive Nitrogen Species (metabolism)</term><term>Receptors, TNF-Related Apoptosis-Inducing Ligand (metabolism)</term><term>Signal Transduction</term><term>TNF-Related Apoptosis-Inducing Ligand (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide peroxynitreux (pharmacologie)</term><term>Antinéoplasiques (pharmacologie)</term><term>Apoptose ()</term><term>Cisplatine (pharmacologie)</term><term>Espèces réactives de l'azote (métabolisme)</term><term>Humains</term><term>Ligand TRAIL (pharmacologie)</term><term>Lignée cellulaire tumorale</term><term>Microdomaines membranaires (métabolisme)</term><term>Récepteurs au TRAIL (métabolisme)</term><term>Résistance aux médicaments antinéoplasiques</term><term>Synergie des médicaments</term><term>Transduction du signal</term><term>Transport de protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Nitrogen Species</term><term>Receptors, TNF-Related Apoptosis-Inducing Ligand</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term><term>Peroxynitrous Acid</term><term>TNF-Related Apoptosis-Inducing Ligand</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Membrane Microdomains</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'azote</term><term>Microdomaines membranaires</term><term>Récepteurs au TRAIL</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide peroxynitreux</term><term>Antinéoplasiques</term><term>Cisplatine</term><term>Ligand TRAIL</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Drug Resistance, Neoplasm</term><term>Drug Synergism</term><term>Humans</term><term>Protein Transport</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Résistance aux médicaments antinéoplasiques</term><term>Synergie des médicaments</term><term>Transduction du signal</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms underlying resistance to cisplatin and unraveling surrogate signaling networks that could revert sensitivity to apoptosis stimuli. We made use of three different sets of cell lines, A549 and H2030 non-small-cell lung cancer (NSCLC) and A2780 ovarian cancer cells and their cisplatin-resistant variants. Here we report that cisplatin-resistant cell lines displayed a multidrug-resistant phenotype. Changes in mitochondrial metabolism and defective mitochondrial signaling were unraveled in the resistant cells. More interestingly, a marked increase in sensitivity of the resistant cells to death receptor-induced apoptosis, in particular TRAIL (TNF-related apoptosis-inducing ligand)-mediated execution, was observed. Although this was not associated with an increase in gene transcription, a significant increase in the localization of TRAIL death receptor, DR4, to the lipid raft subdomains of plasma membrane was detected in the resistant variants. Furthermore, exposure of cisplatin-resistant cells to TRAIL resulted in upregulation of inducible nitric oxide synthase (iNOS) and increase in nitric oxide (NO) production that triggered the generation of peroxynitrite (ONOO<sup>−</sup>). Scavenging ONOO<sup>−</sup> rescued cells from TRAIL-induced apoptosis, thereby suggesting a critical role of ONOO<sup>−</sup> in TRAIL-induced execution of cisplatin-resistant cells. Notably, preincubation of cells with TRAIL restored sensitivity of resistant cells to cisplatin. These data provide compelling evidence for employing strategies to trigger death receptor signaling as a second-line treatment for cisplatin-resistant cancers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Seah, S" sort="Seah, S" uniqKey="Seah S" first="S" last="Seah">S. Seah</name></noRegion><name sortKey="Hirpara, J L" sort="Hirpara, J L" uniqKey="Hirpara J" first="J L" last="Hirpara">J L Hirpara</name><name sortKey="Low, I C C" sort="Low, I C C" uniqKey="Low I" first="I C C" last="Low">I C C. Low</name><name sortKey="Pervaiz, S" sort="Pervaiz, S" uniqKey="Pervaiz S" first="S" last="Pervaiz">S. Pervaiz</name><name sortKey="Pervaiz, S" sort="Pervaiz, S" uniqKey="Pervaiz S" first="S" last="Pervaiz">S. Pervaiz</name><name sortKey="Pervaiz, S" sort="Pervaiz, S" uniqKey="Pervaiz S" first="S" last="Pervaiz">S. Pervaiz</name><name sortKey="Sachaphibulkij, K" sort="Sachaphibulkij, K" uniqKey="Sachaphibulkij K" first="K" last="Sachaphibulkij">K. Sachaphibulkij</name><name sortKey="Seah, S" sort="Seah, S" uniqKey="Seah S" first="S" last="Seah">S. Seah</name></country><country name="France"><noRegion><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name></noRegion><name sortKey="Brenner, C" sort="Brenner, C" uniqKey="Brenner C" first="C" last="Brenner">C. Brenner</name><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name></country><country name="Australie"><noRegion><name sortKey="Pervaiz, S" sort="Pervaiz, S" uniqKey="Pervaiz S" first="S" last="Pervaiz">S. Pervaiz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
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Ou
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{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4632318
|texte= Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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